2020 P1 Q55
Q1. Which one of the following is NOT true regarding Chronic Myeloid Leukaemia (CML)?
- It is a clonal malignancy of haematopoetic stem
- Risk of developing CML is increased in monozygotic turns
- CML is defined by presence of BCR-ABL 1 fusion gene
- 10 year survival with TKI therapy is 85%
Answer & explanation — reveal it in the interactive practice above.
PYQ 2020–2025 — page 21
2024 P1 Q42
Q2. The Rai staging system and Binet staging system are the two widely used staging systems used for staging which of the following hematological malignancies ?
- Acute Myeloid Leukemia
- Chronic Myeloid Leukemia
- Acute Lymphoid Leukemia
- Chronic Lymphocytic Leukemia
Answer & explanation — reveal it in the interactive practice above.
PYQ 2020–2025 — page 291
2023 P1 Q28
Q3. The BCR-ABL 1 oncoprotein exhibits constitutive activity of which one of the following enzymes?
- Alanine kinase
- Tyrosine kinase
- Leucine kinase
- Cysteine kinase
Answer & explanation — reveal it in the interactive practice above.
PYQ 2020–2025 — page 214
2023 P1 Q29
Q4. Imatinib, Dasatinib, Nilotinib and Ponatinib are examples of which class of drugs?
- Interferons
- Monovalent antibodies
- Bivalent antibodies
- Tyrosine kinase inhibitors
Answer & explanation — reveal it in the interactive practice above.
PYQ 2020–2025 — page 214
2025 P1 Q42
Q5. First line therapy in chronic phase of chronic myeloid leukemia is
- Rituximab
- Thalidomide
- Imatinib
- Chlorambucil
Answer & explanation — reveal it in the interactive practice above.
PYQ 2020–2025 — page 385
2022 P1 Q75
Q6. A 40-year-old male presented with complaints of generalized weakness, weight loss, abdominal discomfort, and decreased appetite. On examination, splenomegaly (massive) was present. On investigation, it was found that hemoglobin was 7.0 g/dL, platelet count–8 lakh per cubic mm, WBC–90,000 per cubic mm. Most probably this is the case of
- Chronic lymphocytic leukemia
- Chronic myeloid leukemia
- Acute lymphoblastic leukemia
- Acute myeloid leukemia
Answer & explanation — reveal it in the interactive practice above.
PYQ 2020–2025 — page 161
