Connective tissue disorder — UPSC CMS MCQs (Medicine)

Question 1

Which of the following features are associated with poor prognosis in Diffuse Cutaneous Systemic
1. Sclerosis?
2. Older age
3. A high gas transfer factor for carbon monoxide (TLCO)
4. Proteinuria
Select the correct answer using the code below:

Accepted Answer

C. 1, 3 and 4

Answer

1, 2 and 4

Answer

3 and 4 only

Answer

1, 2 and 3

Question 2

Which one of the following is NOT an appropriate criterion for diagnosis of Systemic Inflammatory Response Syndrome (SIRS)?

Accepted Answer

C. Total leucocyte count > 16 × 10⁹ per litre

Answer

Respiratory rate > 20/min

Answer

Heart rate > 90/min

Answer

Temperature > 38°C

Question 3

Anti-Ribonucleoprotein antibody (Anti-RNP) is characteristically seen in which one of the following conditions?

Accepted Answer

D. Mixed connective tissue disorder

Answer

Sjogren’s syndrome

Answer

Diffuse systemic sclerosis

Answer

Sarcoidosis

Question 4

Schober’s test is used in the assessment of which one of the following clinical conditions?

Accepted Answer

C. Ankylosing Spondylitis

Answer

Rheumatoid arthritis

Answer

Systemic Lupus Erythematosus

Answer

Psoriasis

Question 5

Anti-citrullinated peptide antibody is useful in diagnosis of:

Accepted Answer

A. Rheumatoid arthritis

Answer

Sjogren’s syndrome

Answer

Scleroderma

Answer

Systemic Lupus Erythematosus

Question 6

Which one of the following antibodies is commonly associated with Drug-induced Lupus?

Accepted Answer

C. Anti-histone antibody

Answer

Anti-centromere antibody

Answer

Anti-Jo-1 antibody

Answer

Anti-RNP antibody

Question 7

The best drug for maintenance therapy of Systemic Lupus Erythematosus (SLE) during pregnancy is:

Accepted Answer

A. Hydroxychloroquine

Answer

Sulfasalazine

Answer

Tacrolimus

Answer

Progestins

Question 8

Which of the following crystals are deposited in a case of pseudogout?

Accepted Answer

D. Calcium pyrophosphate dehydrate (CPPD)

Answer

Monosodium urate

Answer

Calcium phosphate

Answer

Cholesterol crystals

Question 9

Which of the following statements regarding Pegloticase are correct?
1. It is an enzyme conjugate.
2. It is useful in chronic gout management.
3. The main adverse effects are infusion reactions and development of antibodies.
Select the correct answer using the code below:

Accepted Answer

D. 1, 2 and 3

Answer

1 and 2 only

Answer

2 and 3 only

Answer

1 and 3 only

Question 10

During physical assessment of a 55-year-old male with low back pain, the quadriceps (knee) reflex was absent. Which of the following nerve roots is most likely to be affected?

Accepted Answer

C. L4

Answer

L2

Answer

L5

Answer

S1

Question 11

Which of the following are correct with regard to Ankylosing spondylitis?
1.Bamboo spine may be seen
2.Early morning back pain is rare
3.Uveitis is the most common extra-articular feature
4.It is more common in males
Select the correct answer using the code below:

Accepted Answer

C. 1, 3, and 4

Answer

1, 2, and 3

Answer

1, 2, and 4

Answer

2, 3, and 4

Question 12

Heberden’s nodes are present mainly in:

Accepted Answer

B. Osteoarthritis

Answer

Rheumatoid arthritis

Answer

Psoriatic arthritis

Answer

Gouty arthritis

Question 13

Urate crystals are described as having the following shape:

Accepted Answer

B. Long and needle-like

Answer

Short and stout

Answer

Small and triangular

Answer

Large and rhomboid

Question 14

Which one of the following terms denotes the extensive sclerosis of the skin of the chest wall which restricts chest wall movement and is seen as a rare complication of systemic sclerosis ?

Accepted Answer

B. Hidebound Chest

Answer

Flail Chest

Answer

Barrel Chest

Answer

Pigeon Chest

Question 15

Which of the following joints are commonly affected in osteoarthritis ?
I. First metatarsophalangeal joint
II. Proximal interphalangeal joint
III. Ankle joint
IV. 5th and 6th cervical vertebrae joint
Select the correct answer using the code given below :

Accepted Answer

C. I, II and IV only

Answer

I and II only

Answer

III and IV only

Answer

I, II, III and IV

Question 16

Which of the following can be used to monitor disease activity in rheumatoid arthritis?
1.Pain (visual analogue scale)
2.X-Ray of hands and wrists
3.DAS 28 score
4.ESR
Select the correct answer using the code below:

Accepted Answer

C. 1, 3, and 4

Answer

1, 2, and 3

Answer

1, 2, and 4

Answer

2, 3, and 4

Question 17

Treatment of first choice in acute Gout is

Accepted Answer

B. Oral Colchicine

Answer

Oral Methotrexate

Answer

Allopurinol

Answer

Sulfasalazine

Q1. Which of the following features are associated with poor prognosis in Diffuse Cutaneous Systemic 1. Sclerosis? 2. Older age 3. A high gas transfer factor for carbon monoxide (TLCO) 4. Proteinuria Select the correct answer using the code below:

Q2. Which one of the following is NOT an appropriate criterion for diagnosis of Systemic Inflammatory Response Syndrome (SIRS)?

Q3. Anti-Ribonucleoprotein antibody (Anti-RNP) is characteristically seen in which one of the following conditions?

Q4. Schober’s test is used in the assessment of which one of the following clinical conditions?

Q5. Anti-citrullinated peptide antibody is useful in diagnosis of:

Q6. Which one of the following antibodies is commonly associated with Drug-induced Lupus?

Q7. The best drug for maintenance therapy of Systemic Lupus Erythematosus (SLE) during pregnancy is:

Q8. Which of the following crystals are deposited in a case of pseudogout?

Q9. Which of the following statements regarding Pegloticase are correct? 1. It is an enzyme conjugate. 2. It is useful in chronic gout management. 3. The main adverse effects are infusion reactions and development of antibodies. Select the correct answer using the code below:

Q10. During physical assessment of a 55-year-old male with low back pain, the quadriceps (knee) reflex was absent. Which of the following nerve roots is most likely to be affected?

Q11. Which of the following are correct with regard to Ankylosing spondylitis? 1.Bamboo spine may be seen 2.Early morning back pain is rare 3.Uveitis is the most common extra-articular feature 4.It is more common in males Select the correct answer using the code below:

Q12. Heberden’s nodes are present mainly in:

Q13. Urate crystals are described as having the following shape:

Q14. Which one of the following terms denotes the extensive sclerosis of the skin of the chest wall which restricts chest wall movement and is seen as a rare complication of systemic sclerosis ?

Q15. Which of the following joints are commonly affected in osteoarthritis ? I. First metatarsophalangeal joint II. Proximal interphalangeal joint III. Ankle joint IV. 5th and 6th cervical vertebrae joint Select the correct answer using the code given below :

Q16. Which of the following can be used to monitor disease activity in rheumatoid arthritis? 1.Pain (visual analogue scale) 2.X-Ray of hands and wrists 3.DAS 28 score 4.ESR Select the correct answer using the code below:

Q17. Treatment of first choice in acute Gout is