Diabetes Mellitus — UPSC CMS MCQs (Medicine)

Question 1

Which one of the following is NOT a criterion for the diagnosis of Diabetes mellitus?

Accepted Answer

D. Fasting plasma glucose ≥ 110 mg/dL

Answer

Symptoms of diabetes and random plasma sugar concentration ≥ 200 mg/dL

Answer

HbA1c ≥ 6.5%

Answer

2-hours plasma glucose ≥ 200 mg/dL during an oral glucose tolerance test

Question 2

A 45-year-old male presented with polyuria, polydipsia, and polyphagia for the last 3 months. His fasting plasma glucose is 106 mg/dL and random blood glucose is 220 mg/dL. Which one of the following statements is correct regarding his diagnosis?

Accepted Answer

B. He has a definitive diagnosis of diabetes mellitus

Answer

He has impaired glucose tolerance (IGT)

Answer

He does not have diabetes mellitus

Answer

Diagnosis of diabetes mellitus is indeterminate as HbA1c value is not provided

Question 3

Which of the following statements with regard to gestational diabetes mellitus (GDM) are correct?
1. Most women revert to normal glucose tolerance post-partum
2. Children born to a GDM mother have no increased risk of diabetes mellitus later in life
3. Glucose intolerance develops during the second and third trimesters
4. Insulin resistance is related to metabolic changes of pregnancy
Select the correct answer using the code:

Accepted Answer

C. 1, 3 and 4

Answer

1, 2 and 3

Answer

1, 2 and 4

Answer

2, 3 and 4

Question 4

Which of the following will be target population for screening of diabetes?
1. Women who have had a baby weighing more than 4.5 kg
2. People over 40 years of age
3. People with family history of diabetes
Select the correct answer using the code:

Accepted Answer

D. 1, 2 and 3

Answer

1 and 2 only

Answer

2 and 3 only

Answer

1 and 3 only

Question 5

Insulin Resistance Syndrome (Syndrome X) is associated with which of the following?
1. Type 2 Diabetes Mellitus
2. Hyperinsulinemia
3. Dyslipidemia
4. Hypercalcemia
Select the correct answer using the code:

Accepted Answer

A. 1, 2 and 3

Answer

1, 2 and 4

Answer

1, 3 and 4

Answer

2, 3 and 4

Question 6

A 15-year-old girl presents to the hospital with severe abdominal pain, vomiting, and cold extremities. She has tachycardia and hypotension. Lab investigations show blood glucose 400 mg/dL, blood pH 6.9, urine ketones +++ and serum creatinine of 1.4 mg/dL. She is promptly administered IV fluids and insulin. After 4 hours, she complains of an inability to lift her limbs. What is the next step to be considered in her management?

Accepted Answer

D. Potassium repletion

Answer

Intravenous normal saline

Answer

Intravenous sodium bicarbonate

Answer

Urine sample for ketones

Question 7

Which one of the following oral anti-diabetic drugs acts on renal proximal tubules?

Accepted Answer

D. SGLT-2 inhibitors

Answer

Alpha glucosidase inhibitors

Answer

GLP-1 analogue

Answer

DPP-4 inhibitors

Question 8

Which of the following are correct with regard to metformin?
1. The maximum tolerated dose is 2000 mg/day
2. Lactic acidosis is the major adverse effect of metformin
3. It may lower the blood levels of Vitamin B12
Select the correct answer using the code:

Accepted Answer

D. 1, 2 and 3

Answer

1 and 2 only

Answer

2 and 3 only

Answer

1 and 3 only

Question 9

Which one of the following drugs used to treat Diabetes mellitus, is least likely to cause hypoglycemia?

Accepted Answer

C. Sitagliptin

Answer

Insulin

Answer

Glimepiride

Answer

Repaglinide

Question 10

Which one of the following statements is true regarding the use of SGLT2 inhibitor in the management of diabetes mellitus?

Accepted Answer

D. Euglycemic diabetic ketoacidosis may occur during treatment if there is a concurrent illness

Answer

They are used in type-1, type-2, and pancreatogenic forms of diabetes mellitus

Answer

They cause an increase in blood pressure by 3-6 mm Hg and hence are avoided in hypertensive patients

Answer

Their glucose-lowering effect is dependent on insulin secretion and insulin sensitivity

Question 11

Which of the following antidiabetic drugs may cause weight gain?
1. Glimepiride
2. Pioglitazone
3. NPH insulin
4. Sitagliptin
Select the correct answer using the code:

Accepted Answer

A. 1, 2 and 3

Answer

1, 2 and 4

Answer

1, 3 and 4

Answer

2, 3 and 4

Question 12

Which one of the following antidiabetic drugs is recommended for weight loss in obese patients?

Accepted Answer

B. Liraglutide

Answer

Glimepiride

Answer

Sitagliptin

Answer

Insulin

Question 13

Which of the following glucose lowering agent can be given as an injectable drug?

Accepted Answer

D. Semaglutide

Answer

Pioglitazone

Answer

Metformin

Answer

Sitagliptin

Question 14

Which of the following are short acting insulin?
1. Aspart
2. Lispro
3. Glargine
4. Regular
Select the correct answer using the code:

Accepted Answer

B. 1, 2 and 4

Answer

1, 2 and 3

Answer

1, 3 and 4

Answer

2, 3 and 4

Question 15

Which of the following is a long-acting insulin?

Accepted Answer

B. Glargine

Answer

Aspart

Answer

Lispro

Answer

Regular

Question 16

Which one of the following insulin preparations has the longest effective duration of action?

Accepted Answer

D. Degludec

Answer

Detemir

Answer

Glargine

Answer

NPH

Question 17

Which of the following insulins has a cloudy preparation and requires resuspension prior to injection?

Accepted Answer

A. Lente

Answer

Glargine

Answer

Detemir

Answer

Degludec

Question 18

Which of the following statements are correct with regard to glucose homeostasis?
1. Insulin level rises postprandially.
2. Major portion of postprandial glucose is used by skeletal muscle.
3. Brain uses glucose in an insulin-dependent manner.
4. Glucagon is secreted during exercise.
Select the correct answer using the code:

Accepted Answer

B. 1, 2 and 4

Answer

1, 2 and 3

Answer

1, 3 and 4

Answer

2, 3 and 4

Question 19

A 52-year-old male diabetic presents with recurrent episodes of hypoglycemia. On examination, Pulse: 84 beats/minute, BP: 160/100 mm Hg, Chest and CVS examination unremarkable. Which of the following antihypertensive should be avoided in this patient?

Accepted Answer

A. Propranolol

Answer

Telmisartan

Answer

Torsemide

Answer

Amlodipine

Q1. Which one of the following is NOT a criterion for the diagnosis of Diabetes mellitus?

Q2. A 45-year-old male presented with polyuria, polydipsia, and polyphagia for the last 3 months. His fasting plasma glucose is 106 mg/dL and random blood glucose is 220 mg/dL. Which one of the following statements is correct regarding his diagnosis?

Q4. Which of the following will be target population for screening of diabetes? 1. Women who have had a baby weighing more than 4.5 kg 2. People over 40 years of age 3. People with family history of diabetes Select the correct answer using the code:

Q5. Insulin Resistance Syndrome (Syndrome X) is associated with which of the following? 1. Type 2 Diabetes Mellitus 2. Hyperinsulinemia 3. Dyslipidemia 4. Hypercalcemia Select the correct answer using the code:

Q7. Which one of the following oral anti-diabetic drugs acts on renal proximal tubules?

Q8. Which of the following are correct with regard to metformin? 1. The maximum tolerated dose is 2000 mg/day 2. Lactic acidosis is the major adverse effect of metformin 3. It may lower the blood levels of Vitamin B12 Select the correct answer using the code:

Q9. Which one of the following drugs used to treat Diabetes mellitus, is least likely to cause hypoglycemia?

Q10. Which one of the following statements is true regarding the use of SGLT2 inhibitor in the management of diabetes mellitus?

Q11. Which of the following antidiabetic drugs may cause weight gain? 1. Glimepiride 2. Pioglitazone 3. NPH insulin 4. Sitagliptin Select the correct answer using the code:

Q12. Which one of the following antidiabetic drugs is recommended for weight loss in obese patients?

Q13. Which of the following glucose lowering agent can be given as an injectable drug?

Q14. Which of the following are short acting insulin? 1. Aspart 2. Lispro 3. Glargine 4. Regular Select the correct answer using the code:

Q15. Which of the following is a long-acting insulin?

Q16. Which one of the following insulin preparations has the longest effective duration of action?

Q17. Which of the following insulins has a cloudy preparation and requires resuspension prior to injection?

Q19. A 52-year-old male diabetic presents with recurrent episodes of hypoglycemia. On examination, Pulse: 84 beats/minute, BP: 160/100 mm Hg, Chest and CVS examination unremarkable. Which of the following antihypertensive should be avoided in this patient?