Neurofibromatosis — UPSC CMS MCQs (Medical Genetics)

Question 1

Which of the following are the clinical features of Neurofibromatosis-1?
1. Angiomas
2. Axillary freckles
3. Cutaneous schwannomas
4. Neurofibromas
Select the correct answer using the code:

Accepted Answer

B. 1, 2 and 4

Answer

1, 2 and 3

Answer

1, 3 and 4

Answer

2, 3 and 4

Question 2

Which of the following chromosomal abnormalities are associated with brain tumours?
1. Neurofibromatosis type 1
2. Neurofibromatosis type 2
3. Peutz-Jeghers syndrome
4. Hereditary nonpolyposis colorectal cancer
Select the correct answer using the code:

Accepted Answer

B. 1, 2 and 4

Answer

1, 2 and 3

Answer

1, 3 and 4

Answer

2, 3 and 4

Question 3

The most common type of brain tumours associated with neurofibromatosis type 1 brain tumour syndrome is:

Accepted Answer

A. astrocytoma

Answer

acoustic neuroma

Answer

meningioma

Answer

medulloblastoma

Question 4

The most common type of brain tumours associated with neurofibromatosis type 1 brain tumour syndrome is

Accepted Answer

A. astrocytoma

Answer

acoustic neuroma

Answer

meningioma

Answer

medulloblastoma

Question 5

Consider the following pairs of genetic diseases that show Mendelian inheritance. Each of the following pairs represents a genetic disease and it has been matched with a type of inheritance:
| Genetic disease | Type of inheritance |
| --- | --- |
| 1. Cystic fibrosis | Autosomal recessive |
| 2. Huntington's chorea | Autosomal dominant |
| 3. Marfan's syndrome | Recessive sex-linked |
How many of the pairs given above are correctly matched?

Accepted Answer

C. Only two of the pairs

Answer

None of the pairs

Answer

Only one of the pairs

Answer

All the three pairs

Question 6

Which one of the following correctly describes the mode of inheritance of haemophilia B?

Accepted Answer

D. X-linked recessive

Answer

Autosomal dominant

Answer

Autosomal recessive

Answer

X-linked dominant

Question 7

Consider the following pairs of genetic diseases that show Mendelian inheritance. Each pair represents a genetic disease matched with a type of inheritance:
1. Cystic fibrosis — Autosomal recessive
2. Huntington’s chorea — Autosomal dominant
3. Marfan’s syndrome — Recessive sex-linked
How many of the pairs given above are correctly matched?

Accepted Answer

C. Only two of the pairs.

Answer

None of the pairs.

Answer

Only one of the pairs.

Answer

All the three pairs.

Q1. Which of the following are the clinical features of Neurofibromatosis-1? 1. Angiomas 2. Axillary freckles 3. Cutaneous schwannomas 4. Neurofibromas Select the correct answer using the code:

Q2. Which of the following chromosomal abnormalities are associated with brain tumours? 1. Neurofibromatosis type 1 2. Neurofibromatosis type 2 3. Peutz-Jeghers syndrome 4. Hereditary nonpolyposis colorectal cancer Select the correct answer using the code:

Q3. The most common type of brain tumours associated with neurofibromatosis type 1 brain tumour syndrome is:

Q4. The most common type of brain tumours associated with neurofibromatosis type 1 brain tumour syndrome is

Q6. Which one of the following correctly describes the mode of inheritance of haemophilia B?