2023 P1 Q35
Q1. Which one of the following conditions characteristically may present with a triad of haemolysis, pancytopenia and venous thrombosis?
- Glucose-6-phosphate dehydrogenase deficiency
- Hereditary spherocytosis
- Hemolytic uremic syndrome
- Paroxysmal nocturnal hemoglobinuria
Answer & explanation — reveal it in the interactive practice above.
PYQ 2020–2025 — page 215
2023 P1 Q88
Q2. Which one of the following is the primary underlying mechanism of haemolysis in paroxysmal nocturnal hemoglobinuria (PNH)?
- ABO incompatibility
- Red cell fragmentation
- Complement-mediated destruction of CD59(-) red blood cells
- Exotoxins produced by Clostridium perfringens
Answer & explanation — reveal it in the interactive practice above.
PYQ 2020–2025 — page 230
2021 P1 Q56
Q3. A 20-year-old young girl presents with heavy menstrual bleeding, petechiae on her arms and blood blisters in mouth. Her complete blood count shows hemoglobin 7 gm/dL, total leucocyte count 8,700 cells/µL and platelet count of 6,000/µL with peripheral smear showing large platelets. Which is likely the best initial drug treatment for this patient?
- High dose glucocorticoids
- High dose glucocorticoids with IVIgG
- High dose glucocorticoids with Rituximab
- IVIgG with anti-Rho(D)
Answer & explanation — reveal it in the interactive practice above.
PYQ 2020–2025 — page 86
2025 P1 Q43
Q4. With regard to management of idiopathic thrombocytopenic purpura, consider the following statements:
I. All patients with ITP with platelet count less than 100×10⁹/L should receive high dose of glucocorticoids
II. For patient with spontaneous bleeding, 40 mg of dexamethasone daily is indicated for 4 days
III. Intravenous immunoglobulin can raise the platelet count
IV. Life threatening bleeding should be treated with platelet transfusion
Select the correct answer using the code:
- I, II and III
- II, III and IV
- I, III and IV
- I, II and IV
Answer & explanation — reveal it in the interactive practice above.
PYQ 2020–2025 — page 385
2021 P2 Q26
Q5. Which of the following are indications of splenectomy?
1. Pseudomyxoma peritonei
2. Trauma
3. Idiopathic thrombocytopenic purpura (ITP)
4. Hypersplenism
Select the correct answer using the code:
- 1, 2 and 3
- 1, 2 and 4
- 1, 3 and 4
- 2, 3 and 4
Answer & explanation — reveal it in the interactive practice above.
PYQ 2020–2025 — page 114
2024 P1 Q71
Q6. Which one of the following statements is characteristic of Purpura fulminans?
- Non-hemorrhagic bullae usually present over extremities
- Present as large ecchymosis with irregular shapes
- Autoimmune disorder and never associated with any infection
- Asplenic patients are protected and do not develop this disease
Answer & explanation — reveal it in the interactive practice above.
PYQ 2020–2025 — page 301
