Vaccine Related — UPSC CMS MCQs (Preventive & Social Medicine)

Question 1

Which one of the following is the correct dose and route of administration of hepatitis B vaccine in children?

Accepted Answer

B. 0.5 mL dose with 10ug of antigen intramuscularly

Answer

0.5 mL dose with 10 ug of antigen subcutaneous

Answer

1 mL dose with 5 ug of antigen subcutaneously

Answer

1 mL dose with 5 ug of antigen intramuscularly

Question 2

Which one of the following statements is correct for approved acellular pertussis vaccine?

Accepted Answer

B. It contains at least 3 pathogenic pertussis antigens

Answer

It contains at least 3 IU of inactivated pertussis toxin

Answer

Its efficacy is superior to the whole cell pertussis vaccine

Answer

Presence of nonfimbrial protein is a mandatory component

Question 3

Pentavalent vaccine provides protection against which of the following diseases?

Accepted Answer

D. Diphtheria, Pertussis, Tetanus, Hepatitis B and Hib

Answer

Diphtheria, Pertussis, Tuberculosis, Measles and Hepatitis B

Answer

Diphtheria, Pertussis, Measles, Hepatitis B and Hib

Answer

Diphtheria, Pertussis, Tetanus, Hepatitis B and Rubella

Question 4

Which one of the following statements regarding sequential administration of Inactivated Polio Vaccine (IPV) and Oral Polio Vaccine (OPV) is NOT correct?

Accepted Answer

C. Intestinal mucosal immunity is lost due to IPV administration

Answer

It will be cost-effective in developing countries for Polio prevention

Answer

The combined schedules of IPV and OPV appear to reduce or prevent Vaccine Associated Paralytic Polio (VAPP)

Answer

IPV and OPV together may optimize both the humoral and mucosal immunogenicity of Polio vaccine

Question 5

Which one of the following is the serological marker of immunization with Hepatitis B vaccine?

Accepted Answer

B. Anti-HBs

Answer

HBsAg

Answer

HBcAg

Answer

Anti-HBc

Question 6

Fractional inactivated intradermal poliovirus vaccine is given at which ages in the National Immunization Schedule?

Accepted Answer

B. 6 weeks and 14 weeks

Answer

6 weeks and 10 weeks

Answer

10 weeks and 14 weeks

Answer

6 weeks, 10 weeks and 14 weeks

Question 7

Hepatitis B vaccine administered at birth is

Accepted Answer

C. A monovalent vaccine of Hepatitis B

Answer

A pentavalent vaccine

Answer

A combined vaccine of inactivated Polio and Hepatitis B

Answer

A fixed combination vaccine of Hib, Hepatitis A and Hepatitis B

Question 8

Which of the following vaccines are given through the intramuscular route?
1. BCG vaccine
2. Hepatitis B vaccine
3. Pentavalent vaccine
4. Inactivated Polio vaccine
Select the correct answer using the code below:

Accepted Answer

A. 2, 3 and 4

Answer

1, 2 and 3

Answer

1, 2 and 4

Answer

1, 3 and 4

Question 9

Covaxin is a/an

Accepted Answer

B. Inactivated whole virus vaccine

Answer

Live attenuated vaccine

Answer

Protein subunit vaccine

Answer

Nucleic acid vaccine

Question 10

Vertical transmission of hepatitis B can be prevented by which of the following interventions?
1.Passive immunization of infant at birth
2.Active immunization of infant at birth
3.Antiviral therapy in the third trimester for mother with HBV-DNA level of > 200,000 IU/mL
Select the correct answer using the code below:

Accepted Answer

D. 1, 2, and 3

Answer

1 and 2 only

Answer

2 and 3 only

Answer

1 and 3 only

Question 11

Which one of the following statements is correct about intra-dermal fractional Inactivated Polio Vaccine (fIPV) with respect to intramuscular (I/M) IPV?

Accepted Answer

B. fIPV is one-fifth of the I/M dose of IPV

Answer

fIPV is one-tenth of the I/M dose of IPV

Answer

fIPV is half of the I/M dose of IPV

Answer

fIPV is three-fourth of the I/M dose of IPV

Question 12

What is the shelf life of Dukoral (wc-rBS) oral vaccine used for cholera prevention, when stored at a temperature of 2°C to 8°C?

Accepted Answer

B. 3 years

Answer

5 years

Answer

1 year

Answer

6 months

Question 13

Which of the following ‘rare vaccine reactions’ are known to occur with the BCG vaccine?
1. Suppurative lymphadenitis
2. Guillain-Barre syndrome
3. Osteitis
4. Disseminated infection
Select the correct answer using the code:

Accepted Answer

B. 1, 2 and 4

Answer

1, 2 and 3

Answer

1, 3 and 4

Answer

2, 3 and 4

Question 14

Vaccine-associated poliomyelitis is chiefly seen with which of the following strains of oral poliovirus?

Accepted Answer

B. OPV 2

Answer

OPV 1 only

Answer

OPV 3 only

Answer

Both OPV 1 and OPV 3

Question 15

The event related to vaccination which can be a contraindication for the next vaccination of a similar/identical type is •

Accepted Answer

B. encephalopathy following DPT vaccine

Answer

syncope following MMR vaccine

Answer

abscess at injection site after DPT vaccine

Answer

gastroenteritis following MMR vaccine

Question 16

Which of the following events could be caused or precipitated by an active component of a vaccine?
Anaphylaxis after measles vaccine
Encephalopathy after DPT vaccine
Adenitis following BCG vaccine
Gastroenteritis following MMR vaccine
Select the correct answer using the code below.

Accepted Answer

A. 1, 2 and 3

Answer

1, 2 and 4

Answer

1, 3 and 4

Answer

2, 3 and 4

Question 17

Which of the following vaccines can be given to a pregnant woman?
(1) COVID vaccine
(2) Measles, Mumps, Rubella vaccine
(3) Hepatitis B vaccine
(4) Rabies vaccine Options:

Accepted Answer

B. 1, 3 and 4

Answer

1, 2 and 3

Answer

2, 3 and 4

Answer

1, 2 and 4

Question 18

Regarding active immunization against typhoid fever, consider the following statements:

Accepted Answer

A. The typhoid polysaccharide vaccine is injectable and can be given subcutaneously or intramuscularly

Answer

The typhoid polysaccharide vaccine is required to be given in two doses and administered on 0 and 7th day

Answer

The typhoid oral Ty21a vaccine requires to be given in three doses on 0, 3rd and 7th days

Answer

Protective immunity with typhoid vaccines is achieved immediately after the vaccine is received. Which of the above statements is/are correct?

Question 19

Which of the following statements are correct regarding the Mantoux test for tuberculosis?

Accepted Answer

B. The injection should be given with the needle bevel facing downward

Answer

It entails injecting 1 TU (Tuberculin Unit) of PPD (Purified Protein Derivative) in 0.1 mL intradermally

Answer

When placed correctly, the injection should produce a pale wheal of the skin, 1 – 2 mm in diameter

Answer

The injection should be given with a tuberculin syringe. Which of the above statements is/are correct?

Question 20

Consider the following vaccines:
1. BCG Vaccine
2. Hepatitis B Vaccine
3. Inactivated Polio Vaccine (IPV)
4. Oral Polio Vaccine (OPV)
Which of the following is the correct order as per their sensitivity to heat (most sensitive to least sensitive) given in NIS?

Accepted Answer

D. 4-3-1-2

Answer

4-3-2-1

Answer

2-1-3-4

Answer

2-1-4-3

Question 21

Which among the following vaccines best represent interventions that focus on cancer prevention too?
Hepatitis A vaccine
Hepatitis B vaccine
Hemophilus influenzae B vaccine
Human papilloma virus vaccine
Choose the correct answer using the code:

Accepted Answer

C. 2 and 4 only

Answer

1 and 2 only

Answer

2 and 3 only

Answer

1 and 4 only

Question 22

Which of the following are correct with regard to BCG vaccination?
1. It is a live-attenuated vaccine.
2. It is administered by intramuscular injection.
3. It is derived from Mycobacterium bovis.
4. It is highly immunogenic. Select the answer
using the code given below:

Accepted Answer

C. 1, 3 and 4

Answer

1, 2 and 3

Answer

2, 3 and 4

Answer

1, 2 and 4

Question 23

Which of the following immunizations are recommended for persons infected with HIV?
1. Hepatitis B vaccine
2. Influenza virus vaccine
3. Pneumococcal vaccine
Select the correct answer using the code below:

Accepted Answer

D. 1, 2 and 3

Answer

1 and 2 only

Answer

2 and 3 only

Answer

1 and 3 only

Question 24

Consider the following statements:
1. Hepatitis B vaccine has reduced efficacy, if administered intramuscularly.
2. The maximum time allowed between reconstitution of MMR vaccine and use is 30 minutes.
3. Maternal antibodies do not interfere with cellular immune response to BCG vaccine.
4. DTwP is preferred to DTaP for primary immunization in most children.
Which of the statements given above are correct?

Accepted Answer

D. 3 and 4

Answer

1 and 2

Answer

1 and 3

Answer

2 and 4

Question 25

Rotavirus vaccination is avoided during an episode of diarrhoea because:

Accepted Answer

A. It might compromise uptake of vaccine

Answer

It could trigger an episode of intussusception

Answer

Rotavirus vaccine is a live vaccine and hence may cause rotavirus diarrhoea and worsen the diarrheal episode

Answer

Vomiting is a significant adverse effect of Rotavirus vaccine

Question 26

In countries with low levels of measles transmission, what should be the appropriate age for starting immunization with measles-containing vaccine (MCV)?

Accepted Answer

C. 12 months

Answer

6 months

Answer

9 months

Answer

15–18 months

Question 27

Which of the following statements are correct regarding vaccination routes for children ?
I. Hepatitis B vaccine given in deltoid region has reduced efficacy
II. Two vaccines may be given in the same thigh, but separated by 1 inch
III. Separate sites are used when administering a vaccine and an immunoglobulin
IV. Two intramuscular vaccines may be given on the same day but in separate limbs
Select the correct answer using the code given below :

Accepted Answer

C. II and III

Answer

III only

Answer

I and III

Answer

I and IV  Final

Question 28

Which of the following statements are correct about oral rotavirus vaccines ?
I. The storage should be at 2–8°C
II. The vaccine should be used within 2 hours of reconstitution or opening
III. Past history of intussusception is a contraindication
IV. The vaccine can be given if the baby has ongoing diarrhoea Select the answer
using the code given below :

Accepted Answer

C. I and III

Answer

I and II

Answer

III and IV

Answer

II and IV

Question 29

Consider the following statements: Statement-1: In the National Immunization Program, BCG vaccine is given only on the left upper arm Statement-2: This is done to maintain uniformity and for helping surveyors in verifying receipt of the vaccine Which one of the following is correct in respect of the above Statements?

Accepted Answer

A. Both Statement-1 and Statement-2 are correct and Statement-2 is the correct

Answer

Both Statement-1 and Statement-2 are correct and Statement-2 is not the correct

Answer

Statement-1 is true but Statement-2 is false

Answer

Statement-1 is false but Statement-2 is true

Question 30

As a part of the Universal Immunization Programme in India, the Inactivated Polio Vaccine (IPV) given as fractional IPV by intradermal route is administered at what age/ages?
1. Birth
2. 6 weeks
3. 14 weeks
4. 9 months
Select the correct answer using the code:

Accepted Answer

C. 2 and 3

Answer

1

Answer

2 only

Answer

2 and 4

Q1. Which one of the following is the correct dose and route of administration of hepatitis B vaccine in children?

Q2. Which one of the following statements is correct for approved acellular pertussis vaccine?

Q3. Pentavalent vaccine provides protection against which of the following diseases?

Q4. Which one of the following statements regarding sequential administration of Inactivated Polio Vaccine (IPV) and Oral Polio Vaccine (OPV) is NOT correct?

Q5. Which one of the following is the serological marker of immunization with Hepatitis B vaccine?

Q6. Fractional inactivated intradermal poliovirus vaccine is given at which ages in the National Immunization Schedule?

Q7. Hepatitis B vaccine administered at birth is

Q8. Which of the following vaccines are given through the intramuscular route? 1. BCG vaccine 2. Hepatitis B vaccine 3. Pentavalent vaccine 4. Inactivated Polio vaccine Select the correct answer using the code below:

Q9. Covaxin is a/an

Q11. Which one of the following statements is correct about intra-dermal fractional Inactivated Polio Vaccine (fIPV) with respect to intramuscular (I/M) IPV?

Q12. What is the shelf life of Dukoral (wc-rBS) oral vaccine used for cholera prevention, when stored at a temperature of 2°C to 8°C?

Q13. Which of the following ‘rare vaccine reactions’ are known to occur with the BCG vaccine? 1. Suppurative lymphadenitis 2. Guillain-Barre syndrome 3. Osteitis 4. Disseminated infection Select the correct answer using the code:

Q14. Vaccine-associated poliomyelitis is chiefly seen with which of the following strains of oral poliovirus?

Q15. The event related to vaccination which can be a contraindication for the next vaccination of a similar/identical type is •

Q16. Which of the following events could be caused or precipitated by an active component of a vaccine? Anaphylaxis after measles vaccine Encephalopathy after DPT vaccine Adenitis following BCG vaccine Gastroenteritis following MMR vaccine Select the correct answer using the code below.

Q17. Which of the following vaccines can be given to a pregnant woman? (1) COVID vaccine (2) Measles, Mumps, Rubella vaccine (3) Hepatitis B vaccine (4) Rabies vaccine Options:

Q18. Regarding active immunization against typhoid fever, consider the following statements:

Q19. Which of the following statements are correct regarding the Mantoux test for tuberculosis?

Q20. Consider the following vaccines: 1. BCG Vaccine 2. Hepatitis B Vaccine 3. Inactivated Polio Vaccine (IPV) 4. Oral Polio Vaccine (OPV) Which of the following is the correct order as per their sensitivity to heat (most sensitive to least sensitive) given in NIS?

Q21. Which among the following vaccines best represent interventions that focus on cancer prevention too? Hepatitis A vaccine Hepatitis B vaccine Hemophilus influenzae B vaccine Human papilloma virus vaccine Choose the correct answer using the code:

Q22. Which of the following are correct with regard to BCG vaccination? 1. It is a live-attenuated vaccine. 2. It is administered by intramuscular injection. 3. It is derived from Mycobacterium bovis. 4. It is highly immunogenic. Select the answer using the code given below:

Q23. Which of the following immunizations are recommended for persons infected with HIV? 1. Hepatitis B vaccine 2. Influenza virus vaccine 3. Pneumococcal vaccine Select the correct answer using the code below:

Q25. Rotavirus vaccination is avoided during an episode of diarrhoea because:

Q26. In countries with low levels of measles transmission, what should be the appropriate age for starting immunization with measles-containing vaccine (MCV)?

Q30. As a part of the Universal Immunization Programme in India, the Inactivated Polio Vaccine (IPV) given as fractional IPV by intradermal route is administered at what age/ages? 1. Birth 2. 6 weeks 3. 14 weeks 4. 9 months Select the correct answer using the code: